T/CITS233—2025ICS11.100 CCSC05 液相色谱-质谱联用用于脂溶性维生素检 测通用技术要求 Generaltechnicalrequirementsformeasurementoffat-soluble vitaminsbyliquidchromatography-massspectrometry 2025-01-16发布 2025-01-16实施 发布CITS 全国团体标准信息平台 全国团体标准信息平台 T/CITS233—2025 I目次 前言..............................................................................III 1范围.............................................................................1 2规范性引用文件...................................................................1 3术语和定义.......................................................................1 4缩略语...........................................................................2 5实验基本要求.....................................................................2 5.1实验室基本要求.............................................................2 5.2人员要求...................................................................2 5.3液相色谱串联质谱（LC—MS/MS）设备的基本要求................................2 5.4样品采集、运输和存储要求...................................................3 5.5试剂和耗材.................................................................3 6方法学建立.......................................................................3 6.1概述.......................................................................3 6.2标准品和内标的选择.........................................................3 7方法学验证.......................................................................4 7.1方法学验证参数.............................................................4 7.2精密度验证.................................................................4 7.3正确度评价.................................................................4 7.4线性.......................................................................5 7.5可报告范围.................................................................5 7.6定量下限...................................................................5 7.7参考区间/切点..............................................................5 7.8选择性或特异性.............................................................5 7.9携带污染率.................................................................5 7.10基质效应..................................................................6 7.11可比性验证................................................................6 8质量管理.........................................................................6 8.1室内质控...................................................................6 全国团体标准信息平台 T/CITS233—2025 II8.2室间质量评价...............................................................7 8.3其它质量保证和质量控制措施.................................................7 9结果报告.........................................................................7 附录A（资料性）血清脂溶性维生素液相色谱—质谱联用法（液液萃取方法）...............8 参考文献...........................................................................11 全国团体标准信息平台