论文标题
具有短距离相关性的动态过程的多尺度部分信息分解:理论和应用心血管控制
Multiscale Partial Information Decomposition of Dynamic Processes with Short and Long-range correlations: Theory and Application to Cardiovascular Control
论文作者
论文摘要
心率变异性来自多种生理系统的联合活性,包括具有自己内部调节的心脏,血管和呼吸系统,但也相互相互作用以保持体内稳态功能。这些控制机制在多个时间尺度上运行,从而导致短期动力学和远程相关性同时存在。网络生理框架提供了基于信息理论的统计工具,能够量化多变量和多尺度互连机制的结构方面,推动了复杂生理网络的动态。在这项工作中,使用矢量自动化自动化分数集成(VARFI)框架获得了高斯工艺的矢量自动化效果,从而获得了从收缩压(S)和呼吸(R)转移到心脏周期(H)及其分解为心脏周期(H)的多尺度表示。这种新颖的方法允许量化有针对性的信息流,以同时存在分析过程中的短期动力学和远程相关性。该方法首先在模拟的VARFI过程中说明,然后应用于在静止和心理和姿势压力下监测的健康受试者中测量的H,S和R时间序列。我们的结果突出了信息传输对耦合动力学系统短期和远程相关性之间平衡的依赖性,这是无法使用不考虑远程相关性的标准方法观察到的。提出的方法表明,姿势应力在短时间尺度上会引起较大的冗余效果,而精神应力会在较长的时间尺度上诱导更大的心血管信息转移。
Heart rate variability results from the combined activity of several physiological systems, including the cardiac, vascular, and respiratory systems which have their own internal regulation, but also interact with each other to preserve the homeostatic function. These control mechanisms operate across multiple temporal scales, resulting in the simultaneous presence of short-term dynamics and long-range correlations. The Network Physiology framework provides statistical tools based on information theory able to quantify structural aspects of multivariate and multiscale interconnected mechanisms driving the dynamics of complex physiological networks. In this work, the multiscale representation of Transfer Entropy from Systolic Arterial Pressure (S) and Respiration (R) to Heart Period (H) and of its decomposition into unique, redundant and synergistic contributions is obtained using a Vector AutoRegressive Fractionally Integrated (VARFI) framework for Gaussian processes. This novel approach allows to quantify the directed information flow accounting for the simultaneous presence of short-term dynamics and long-range correlations among the analyzed processes. The approach is first illustrated in simulated VARFI processes and then applied to H, S and R time series measured in healthy subjects monitored at rest and during mental and postural stress. Our results highlight the dependence of the information transfer on the balance between short-term and long-range correlations in coupled dynamical systems, which cannot be observed using standard methods that do not consider long-range correlations. The proposed methodology shows that postural stress induces larger redundant effects at short time scales and mental stress induces larger cardiovascular information transfer at longer time scales.