论文标题
对MR和超声检查的PVC Plastisol组织模拟幻象的研究
Investigation of PVC plastisol tissue-mimicking phantoms for MR-and ultrasound-elastography
论文作者
论文摘要
目的：逼真的模拟幻影对于医学成像技术和协议的开发，研究和校准至关重要。由于它需要考虑机械和成像特性，因此稳健，校准的幻影的发展是弹性摄影的主要挑战。已经提出，液体增塑剂（Plastisol或PVCP）中的软聚氯乙烯凝胶已被提议作为模拟组织幻像（TMP）进行弹性成像。 PVCP幻影的成本相对较低，可以在长期内容易存储而无需任何特定要求。在这项工作中，提出了PVCP凝胶幻象为MR和超声检查学的制备，并研究了其声学，NMR和机械性能。材料和方法：pVCP的声学和磁共振成像特性在超声型粒料和PVCP之间的不同质量率之间测量了PVCP的声音和磁共振成像。然后，随着时间的推移，不仅使用压痕测试，还可以对Plastisol样品的线性机械性能进行研究，还研究了MR和超声弹性临床方案。将这些特性与报道的生物软组织报告的典型值以及PVCP凝胶的文献中发现的值进行了比较。结果和结论：两周后，用压痕测试测量的塑料样品的机械性能稳定至少在接下来的4周后43天后43天（凝胶化结束后43天结束）。塑料凝胶的机械性和NMR特性都没有被添加为声音散布的纤维素影响。所提出的凝胶的机械性能通过临床，商业上可用的MR弹性和声弹性图协议成功地表征。超声斑点颗粒质量比为0.6％至0.8％的PVCP，在50％至70％之间的树脂和增塑剂之间的质量比为质量比，作为一个可以与基于MR和Ultrasound的弹性方法一起使用的良好TMP候选者。
Objective: Realistic tissue-mimicking phantoms are essential for the development, the investigation and the calibration of medical imaging techniques and protocols. Because it requires taking both mechanical and imaging properties into account, the development of robust, calibrated phantoms is a major challenge in elastography. Soft polyvinyl chloride gels in a liquid plasticizer (plastisol or PVCP) have been proposed as soft tissue-mimicking phantoms (TMP) for elasticity imaging. PVCP phantoms are relatively low-cost and can be easily stored over long time periods without any specific requirements. In this work, the preparation of a PVCP gel phantom for both MR and ultrasoundelastography is proposed and its acoustic, NMR and mechanical properties are studied.Material and methods: The acoustic and magnetic resonance imaging properties of PVCP are measured for different mass ratios between ultrasound speckle particles and PVCP solution, and between resin and plasticizer. The linear mechanical properties of plastisol samples are then investigated over time using not only indentation tests, but also MR and ultrasound-elastography clinical protocols. These properties are compared to typical values reported for biological soft tissues and to the values found in the literature for PVCP gels.Results and conclusions: After a period of two weeks, the mechanical properties of the plastisol samples measured with indentation testing are stable for at least the following 4 weeks (end of follow-up period 43 days after gelation-fusion). Neither the mechanical nor the NMR properties of plastisol gels were found to be affected by the addition of cellulose as acoustic speckle. Mechanical properties of the proposed gels were successfully characterized by clinical, commercially-available MR Elastography and sonoelastography protocols. PVCP with a mass ratio of ultrasound speckle particles of 0.6% to 0.8% and a mass ratio between resin and plasticizer between 50 and 70% appears as a good TMP candidate that can be used with both MR and ultrasound-based elastography methods.
