论文标题

使用Terahertz通信的受控蛋白质相互作用的信息率

Information Rates of Controlled Protein Interactions Using Terahertz Communication

论文作者

Elayan, Hadeel, Eckford, Andrew W., Adve, Raviraj

论文摘要

在这项工作中,我们提出了通过刺激反应性体内模型的范式桥接电磁(EM)和分子通信。已经确定,在控制细胞行为中起关键作用的蛋白质分子可以使用Terahertz(THZ)带频率选择性刺激。通过使用THZ波触发蛋白质振动模式,我们诱导蛋白质构象的变化,从而激活了受控的生化和生物力学事件的级联反应。为了分析这种相互作用,我们制定了一个由纳米ante发射器和蛋白质接收器组成的通信系统。我们采用马尔可夫链模型来说明蛋白质的随机性,其过渡速率由纳米坦纳力控制。两态和多态蛋白质模型均显示为描述不同的生物构构。得出和最大化每种情况的相互信息的封闭形式表达式,以找到输入纳米反滕纳力与蛋白质状态之间的能力。我们获得的结果表明,受控的蛋白质信号传导为纳米坦纳和蛋白质之间的信息传递提供了通信平台,其物理意义清晰。这项工作中报道的分析应进一步研究基于EM的蛋白质网络的控制。

In this work, we present a paradigm bridging electromagnetic (EM) and molecular communication through a stimuli-responsive intra-body model. It has been established that protein molecules, which play a key role in governing cell behavior, can be selectively stimulated using Terahertz (THz) band frequencies. By triggering protein vibrational modes using THz waves, we induce changes in protein conformation, resulting in the activation of a controlled cascade of biochemical and biomechanical events. To analyze such an interaction, we formulate a communication system composed of a nanoantenna transmitter and a protein receiver. We adopt a Markov chain model to account for protein stochasticity with transition rates governed by the nanoantenna force. Both two-state and multi-state protein models are presented to depict different biological configurations. Closed form expressions for the mutual information of each scenario is derived and maximized to find the capacity between the input nanoantenna force and the protein state. The results we obtain indicate that controlled protein signaling provides a communication platform for information transmission between the nanoantenna and the protein with a clear physical significance. The analysis reported in this work should further research into the EM-based control of protein networks.

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