论文标题
预测公共卫生的传染病
Infectious Disease Forecasting for Public Health
论文作者
论文摘要
预测传染病的传播,尤其是对于媒介传播疾病,对研究人员构成了独特的挑战。病毒,载体,宿主和环境之间的行为和相互作用在确定疾病的传播中起着作用。公共卫生监视系统和其他来源提供了有价值的数据,可用于准确预测疾病的发生率。但是,常见的传染病监测数据的许多方面是不完美的:案例可能会延迟或在某些情况下根本没有报告,可能无法提供有关矢量的数据,并且在高地理或时间分辨率下可能无法提供病例数据。面对这些挑战,研究人员必须假设在机械模型中说明这些基本过程,或者在统计模型中完全证明其排除。是模型是机械的还是统计的,研究人员应使用新兴的传染病预测领域接受的最佳实践来评估其模型,同时采用数十年来开发预测方法的其他领域的约定。对假设的会计和正确评估模型将使研究人员能够产生有可能为公共卫生官员提供宝贵见解的预测。本章提供了一般预测的实践的背景,讨论了用于传染病预测的生物学和统计模型,介绍了有关制作和评估预测模型的技术细节,并探讨了在公共卫生环境中沟通预测的问题。
Forecasting transmission of infectious diseases, especially for vector-borne diseases, poses unique challenges for researchers. Behaviors of and interactions between viruses, vectors, hosts, and the environment each play a part in determining the transmission of a disease. Public health surveillance systems and other sources provide valuable data that can be used to accurately forecast disease incidence. However, many aspects of common infectious disease surveillance data are imperfect: cases may be reported with a delay or in some cases not at all, data on vectors may not be available, and case data may not be available at high geographical or temporal resolution. In the face of these challenges, researchers must make assumptions to either account for these underlying processes in a mechanistic model or to justify their exclusion altogether in a statistical model. Whether a model is mechanistic or statistical, researchers should evaluate their model using accepted best practices from the emerging field of infectious disease forecasting while adopting conventions from other fields that have been developing forecasting methods for decades. Accounting for assumptions and properly evaluating models will allow researchers to generate forecasts that have the potential to provide valuable insights for public health officials. This chapter provides a background to the practice of forecasting in general, discusses the biological and statistical models used for infectious disease forecasting, presents technical details about making and evaluating forecasting models, and explores the issues in communicating forecasting results in a public health context.