论文标题
绝对乙醇摄入驱动果蝇中的乙醇偏好
Absolute ethanol intake drives ethanol preference in Drosophila
论文作者
论文摘要
介导果蝇中乙醇偏好的因素尚不清楚。一个主要的混淆是使用各种方法来估计消耗乙醇。我们测量了在营养，味道和乙醇浓度变化的碱饮食上的苍蝇消费乙醇偏好。两性均表现出在高营养浓度饮食中废除的乙醇偏好。此外，在不改变碱性饮食或乙醇浓度的营养价值的情况下操纵总食物摄入量足以引起或消除乙醇偏好。与热量摄入量或饮食热量含量相比，绝对的乙醇摄入量和消耗的食物量是乙醇偏好的预测指标。我们的发现表明，碱性饮食对乙醇偏好的影响很大程度上是由与递送介质相关的总消费介导的，这最终决定了乙醇摄入的水平。我们推测，乙醇摄入的生理相关阈值对于优先乙醇消耗至关重要。
Factors that mediate ethanol preference in Drosophila melanogaster are not well understood. A major confound has been the use of diverse methods to estimate ethanol consumption. We measured fly consumptive ethanol preference on base diets varying in nutrients, taste, and ethanol concentration. Both sexes showed ethanol preference that was abolished on high nutrient concentration diets. Additionally, manipulating total food intake without altering the nutritive value of the base diet or the ethanol concentration was sufficient to evoke or eliminate ethanol preference. Absolute ethanol intake and food volume consumed were stronger predictors of ethanol preference than caloric intake or the dietary caloric content. Our findings suggest that the effect of the base diet on ethanol preference is largely mediated by total consumption associated with the delivery medium, which ultimately determines the level of ethanol intake. We speculate that a physiologically relevant threshold for ethanol intake is essential for preferential ethanol consumption.
