论文标题
冠状病毒Nucleocapsid的结构模型
A structural model for the Coronavirus Nucleocapsid
论文作者
论文摘要
我们提出了一个冠状病毒Nucleocapsid的中尺度模型结构，该结构是根据N蛋白基本构建块的高分辨率结构组装而成的，冷冻成像和数学约束的总体准确粒子。该结构是一个截断的八面体，可容纳两层：由N末端结构域的三角形和四角形晶格组成的外壳，以及C-末端结构域盘旋平行螺旋的等效晶格的内壳。该模型与包装大型病毒基因组的预期尺寸一致，并提供了解释冠状病毒明显多形性质的理由。
We propose a mesoscale model structure for the coronavirus nucleocapsid, assembled from the high resolution structures of the basic building blocks of the N-protein, CryoEM imaging and mathematical constraints for an overall quasi-spherical particle. The structure is a truncated octahedron that accommodates two layers: an outer shell composed of triangular and quadrangular lattices of the N-terminal domain and an inner shell of equivalent lattices of coiled parallel helices of the C-terminal domain. The model is consistent with the dimensions expected for packaging large viral genomes and provides a rationale to interpret the apparent pleomorphic nature of coronaviruses.
